How is UCP1 regulated?
How is UCP1 regulated? UCP1 activity is highly regulated at the molecular level by small molecules. It is inhibited by physiological concentrations of purine nucleoside di- and tri-phosphates and stimulated when fatty acids overcome nucleotide inhibition [12]. How fatty acids activate the net protonophoric activity of UCP1 is still debated. How is UCP1 activated? UCP1 is activated by long-chain fatty acids (LCFAs) that are produced within brown adipocytes by the lipolysis of cytoplasmic lipid droplets upon adrenergic stimulation of BAT (Cannon and Nedergaard, 2004). What is the role of UCP1? Uncoupling protein 1 (UCP1), originally termed thermogenin owing to its...