What are imputed SNPs?
What are imputed SNPs?
Only a subset of single-nucleotide polymorphisms (SNPs) can be genotyped in genome-wide association studies. Imputation methods can infer the alleles of ‘hidden’ variants and use those inferences to test the hidden variants for association.
What happened to HapMap?
The HapMap Project released its third and final dataset in 2009. While this project is no longer active, data that was collected from the project is still freely available to researchers worldwide. Researchers can use the data to learn more about the relationship between genetic differences and human disease.
Who owns the HapMap?
The International HapMap Project is a partnership of scientists and funding agencies from Canada, China, Japan, Nigeria, the United Kingdom and the United States.
What is HapMap3?
HapMap 3 is the third phase of the International HapMap project. This phase increases the number of DNA samples covered from 270 in phases I and II to 1,301 samples from a variety of human populations. This is the draft release 3. The definitive data are available from the HapMap ftp site.
How many SNPs are needed for imputation?
31 163 897
The CAAPA reference panel contains whole-genome sequences for 883 samples recruited into 19 case-control studies on asthma in the Americas. A total of 31 163 897 autosomal SNPs are included on the panel for imputation (Mathias et al., 2016).
What is the synonyms of impute?
Some common synonyms of impute are ascribe, assign, attribute, and credit. While all these words mean “to lay something to the account of a person or thing,” impute suggests ascribing something that brings discredit by way of accusation or blame.
How many SNPs were Catalogued by HapMap?
3 million SNPs
What was the project’s scientific strategy? To develop the HapMap, the samples were genotyped for 3 million SNPs across the human genome.
Which countries are involved in the international HapMap project?
The International HapMap Project is a collaboration among researchers at academic centers, non-profit biomedical research groups and private companies in Canada, China (including Hong Kong), Japan, Nigeria, the United Kingdom, and the United States.
What are HapMap populations?
A set of associated SNP alleles in a region of a chromosome is called a haplotype. Most chromosome regions have only a few common haplotypes, which account for most of the variation from person to person in a population. The HapMap describes the common patterns of genetic variation in humans.
How accurate is imputation?
Imputation accuracy has previously been assessed for African populations (Huang et al., 2009; Hancock et al., 2012; Roshyara et al., 2016) and for populations with two- or three-way admixture, with results reaching over 75% accuracy (Nelson et al., 2016).