What is imatinib mesylate used for?

Imatinib mesylate is approved to treat: Acute lymphoblastic leukemia in adults and children that is Philadelphia chromosome positive. In adults, it is used for disease that has recurred (come back) or is refractory (does not respond to treatment).

What is the brand name for imatinib mesylate?

Gleevec is the trade name for the generic drug name Imatinib Mesylate. STI-571 is another name for Imatinib Mesylate. In some cases, health care professionals may use the trade name Gleevec or other name STI-571 when referring to the generic drug name Imatinib Mesylate.

How do you dissolve imatinib mesylate?

Imatinib mesylate is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide. The solubility of imatinib mesylate in these solvents is approximately 0.2, 14, and 10 mg/ml, respectively.

Is imatinib a chemotherapy drug?

Chemo was once one of the main treatments for CML. It’s seldom used now because TKIs like imatinib (Gleevec®) work much better. Today, chemo may be used to treat CML when the TKIs have stopped working. It’s also used as part of a stem cell transplant.

Can CML be cured?

Although a bone marrow transplant is the only treatment that can cure CML, it is used less often now. This is because bone marrow transplants have a lot of side effects, while TKIs are very effective for CML and have fewer side effects.

What cancers does imatinib treat?

Imatinib is used to treat certain types of leukemia (cancer that begins in the white blood cells) and other cancers and disorders of the blood cells.

Is Gleevec a TKI?

Drugs known as tyrosine kinase inhibitors (TKIs) that target BCR-ABL are the standard treatment for CML. These include: Imatinib (Gleevec)

Who makes Gleevec?

Teva Pharmaceutical Industries has announced the launch of a generic version of imatinib mesylate, which is currently manufactured by Novartis and is sold under the brand name Gleevec.

Does imatinib cause hair loss?

In most cases, the drug is well tolerated: however, side effects can be seen. Hair loss and paronychia inflammation were often reported with Imatinib, but total alopecia was rarely mentioned. We report a CML patient who was presented with alopecia and paronychia inflammation probably induced by imatinib therapy.

Can I take vitamin D with imatinib?

Based on interaction studies of imatinib with the cytochrome P450 (CYP450) inhibitors VID400 and ketoconazole, it is proposed that imatinib may interfere with the vitamin D3 cascade due to its metabolism by CYP27B1, which is involved in vitamin D3 metabolism.

Is imatinib mesylate cytotoxic?

Therefore, imatinib (Gleevec) is selective in leukemia. 4,5 It is cytotoxic to Bcr-Abl-containing leukemia cells and thus, selectively cytotoxic.

Can I live a normal life with CML?

While patients with CML are fortunate to have excellent therapies available to control their disease, most do not lead normal lives due to the diminished health-related quality of life that is associated with long term treatment.