What medication is contraindicated with cisplatin?

Avoid or Use Alternate Drug. cidofovir and cisplatin both increase nephrotoxicity and/or ototoxicity. Avoid or Use Alternate Drug. Concomitant use of cidofovir and agents with nephrotoxic potential is contraindicated.

How do you reduce the toxicity of cisplatin?

The standard approach for prevention of CIN is the administration of lower doses of cisplatin in combination with full intravenous hydration prior and after cisplatin administration. Cisplatin-induced oxidative stress in the kidney may be prevented by natural antioxidant compounds.

What do I give cisplatin with?

Hydration is recommended to induce diuresis and reduce the concentration of cisplatin in the kidneys. Isotonic saline (0.9% sodium chloride) is recommended for hydration fluids, and many centers also include potassium and magnesium in these hydration fluids due to the risk of electrolyte wasting.

Is cisplatin the strongest chemo?

Platinum-based chemotherapy drugs are among the most powerful and widely used against cancer. However, they have toxic side effects, and tumors can become resistant to them. Cisplatin, the most common platinum chemotherapy drug, was first approved in the US in 1978.

Can I drink alcohol with cisplatin?

Avoid drinks with caffeine or alcohol. You may have 1 cup (8 ounces) of caffeinated coffee or tea per day.

Is cisplatin toxic?

Cisplatin treatment has been linked to various toxic side effects including nausea, nephrotoxicity, Cardiotoxicity, hepatotoxicity and neurotoxicity. Many toxic events have been reported in various studies that include arrhythmias, congestive heart failure, electro-cardiographicchanges as well as myocarditis.

Does cisplatin cause neurotoxicity?

The range of cisplatin-induced neurotoxicity includes peripheral neuropathy, ototoxicity (hearing impairment and tinnitus), vestibulopathy, and encephalopathy; the most common are peripheral neuropathy and ototoxicity.

How does cisplatin affect the kidneys?

In addition, cisplatin may cause renal vasoconstriction through injury on the renal vasculature, which reduces blood flow, causing ischemic damage to the kidney and affects the glomerular filtration rate. Finally, a series of adverse reactions trigger acute renal failure.

How much water should I drink with cisplatin?

Drink 8 to 12 (8-ounce) glasses of liquids every day for 1 week after your treatment. Take your anti-nausea medications as recommended by your doctor. Remember that it’s especially important to drink enough liquids for the first 2 days after getting cisplatin chemotherapy.

How long does it take for cisplatin to leave the body?

The first elimination half-life (t1/2) for cisplatin was 5.02 months and the second 37.0 months. For oxaliplatin, these half-lifes were 1.37 and 535 months.