How fast should meropenem be infused?

Meropenem for injection (I.V.) should be administered by intravenous infusion over approximately 15 minutes to 30 minutes. Doses of 1 gram may also be administered as an intravenous bolus injection (5 mL to 20 mL) over approximately 3 minutes to 5 minutes.

How do you dilute meropenem for infusion?

Meropenem to be used for bolus intravenous injection should be reconstituted with sterile water for injection. For intravenous infusion, meropenem vials may be directly reconstituted with 0.9 % sodium chloride or 5% glucose solutions for infusion.

Why is meropenem given over 3 hours?

Conclusions: Compared with conventional regime of 30-minute infusion of meropenem in the treatment of HAP in ICU patients, the clinical efficacy can be improved, the severity of the disease can be reduced, the recovery of organ failure and long-term prognosis can be improved with 3 hour extended infusion of meropenem.

Can meropenem be given as prolonged infusion?

Meropenem exhibits time-dependent antimicrobial activity and prolonged infusion (PI) (extended infusion or continuous infusion, EI or CI) of meropenem can better achieve pharmacodynamics target when comparing with intermittent bolus (IB).

How do you dilute vancomycin IV?

Reconstituted solutions containing 1g vancomycin must be diluted with at least 200ml diluent. 0.9% sodium chloride intravenous infusion or 5% dextrose intravenous infusion are suitable diluents. The desired dose should be given by intravenous infusion over a period of at least 60 minutes.

How long is meropenem stable for?

According to the package labeling, reconstituted solutions of meropenem retain stability for only 1-24 hours, depending on the diluent, the concentration, and the storage temperature.

How do you mix meropenem IM?

A solution for infusion is prepared by dissolving the drug product meropenem in either 0.9% sodium chloride solution for infusion or 5% glucose (dextrose) solution for infusion to a final concentration of 1 to 20 mg/ml.

How fast can meropenem be given IV?

Meropenem is usually given by intravenous infusion over approximately 15 to 30 minutes (see section 6.2, 6.3 and 6.6). Alternatively, doses up to 1 g can be given as an intravenous bolus injection over approximately 5 minutes.

How long does meropenem take to work?

How long does meropenem take to work? In Meningitidis, it takes 7–10 days. In influenzae type b infection, it takes 10–14 days for pneumoniae infection.

What is a continuous infusion?

Listen to pronunciation. (kon-TIN-yoo-us in-FYOO-zhun) The administration of a fluid into a blood vessel, usually over a prolonged period of time.

What is prolonged infusion?

Prolonged infusions attain the pharmacodynamic efficacy target defined for beta-lactam antibiotics more effectively than short infusions. Thus, a prolonged infusion administration strategy may improve microbiologic and clinical cure, especially when pathogens demonstrate higher minimum inhibitory concentrations (MIC).

What is the maximum infusion rate for vancomycin?

Vancomycin shall only be administered as slow intravenous infusion of at least one hour duration or at a maximum rate of 10 mg/min (whichever is longer) which is sufficiently diluted (at least 100 ml per 500 mg or at least 200 ml per 1000 mg) (see section 4.4).