How many people are affected by Gorham-Stout disease?

More than 300 affected individuals have been reported in the medical literature. Because GSD is so rare, many cases go undiagnosed or misdiagnosed making it difficult to determine the disorder’s true frequency in the general population.

Is Gorham-Stout disease fatal?

The rate of progression is unpredictable and the prognosis can be difficult. The disease may stabilize after a number of years, go into spontaneous remission, or, in cases involving the chest and upper spine, prove fatal. Recurrence of the disease following remission can also occur.

Can Gorham-Stout disease be cured?

Surgery alone cannot cure Gorham-Stout. However, your child’s physician may recommend a surgical procedure to stabilize or remove affected bone, or to treat symptoms and complications related to the disease.

How do you get Gorham’s disease?

The cause of Gorham-Stout is unknown. There is no evidence that the disease is hereditary or caused by environmental factors. However, active research is underway at Boston Children’s and other institutions to possibly identify a mutation that could cause the lymphatic and bone disorder.

What is the rarest bone disease?

Collapse Section. Melorheostosis is a rare bone disease. It causes the abnormal growth of new bone tissue on the surface of existing bones.

What eats away at bone?

Cancer cells that spread from tumors in other parts of the body can form two main types of bone tumors: The tumor may eat away areas of bone. This creates holes called osteolytic lesions. They can make bones fragile and weak.

What is the treatment for Gorham’s disease?

The medical treatment for Gorham’s disease includes radiation therapy, anti-osteoclastic medications (bisphosphonates), and alpha-2b interferon. Surgical treatment options include resection of the lesion and reconstruction using bone grafts and/or prostheses.

Who discovered Gorham-Stout disease?

Gorham-Stout disease was initially described by Jackson in 1838 and later classified by Gorham and Stout in 1955 [3, 4]. Worldwide, considering all the potential affected regions only 200 cases have been reported. Osteolysis can affect any bone. It is associated with functional deficits and pain [5].

When was Gorham-Stout disease discovered?

The first case of Gorham-Stout disease was already reported in 1838 and described a patient with a vanishing of the complete humerus bone over 11 years (19). After more than a century, in 1955, Gorham and Stout investigated the characteristic histopathological findings of the massive osteolysis based on 8 cases.

Are tomatoes bad for osteoporosis?

“Nightshade vegetables, such as tomatoes, mushrooms, peppers, white potatoes, and eggplant, can cause bone inflammation, which can lead to osteoporosis,” Khader says. However, these vegetables contain other vitamins and minerals that are good for your health so, like beans, they shouldn’t be totally avoided.

What is Gorham’s disease?

What is Gorham’s disease? Gorham’s disease is a rare bone disorder characterized by bone loss (osteolysis), often associated abnormal blood vessel growth (angiomatous proliferation). Bone loss can occur in just one bone, or spread to soft tissue and adjacent bones.

What is GSD (Gorham-Stout disease)?

Gorham-Stout Disease (GSD) is a very rare, progressive disorder of the bone. It is characterized by bone loss (or osteolysis), and a swelling or abnormal growth of blood vessels (angiomatous proliferation) and lymph vessels (lymphangiomatous proliferation), inside the bones. The exact cause of the disorder is not known.

What is gregorham’s disease?

Gorham’s disease is a rare bone disorder characterized by bone loss (osteolysis), often associated abnormal blood vessel growth (angiomatous proliferation).

Is Gorham-Stout syndrome a monocentric bone disease?

In 1999, Möller and colleagues[4]concluded, “The Gorham-Stout syndrome may be, essentially, a monocentric bone disease with a focally increased bone resorption due to an increased number of paracrine– or autocrine– stimulated hyperactive osteoclasts. The resorbed bone is replaced by a markedly vascularizedfibrous tissue.