Is pravastatin more potent than simvastatin?

At the recommended starting dose, simvastatin had a significantly greater lipid-lowering effect than pravastatin. These results may have implications for the appropriate lipid-reduction therapy for patients at risk of coronary heart disease.

Which statin is most potent?

Rosuvastatin is the latest and most potent statin currently on the market.

What is the difference in potency between statin drugs?

Dose for dose, atorvastatin is more potent than simvastatin at blocking the target enzyme, HMGCoA; this effect is overcome by using a higher dose of simvastatin. In controlled dosing studies, simvastatin 40 mg and atorvastatin 10 mg and 20 mg are equally effective.

How is simvastatin different from pravastatin?

Zocor (simvastatin) is a good medication to improve your cholesterol. Lowers cholesterol. Pravachol (pravastatin) can improve cholesterol, but it’s not as strong as other statin medicines. It does cause fewer side effects and is safer for your kidneys and liver.

Is pravastatin the safest statin?

Atorvastatin (Lipitor), simvastatin and pravastatin were the most commonly used statins among participants. Simvastatin and pravastatin had the best safety profile, according to this review.

Can you take simvastatin and pravastatin together?

Lovastatin (Mevacor), simvastatin (Zocor) and pravastatin (Pravachol) should not be used with the fibrate cholesterol drug gemfibrozil, for example, because of the risk of muscle injury. Dr. Thomas Whayne, a professor of medicine at the University of Kentucky’s Gill Heart Institute, agreed.

Is pravastatin the best statin?

One of the first and best studied statins is pravastatin, which has been studied in both primary and secondary prevention trials. With 40 mg pravastatin daily, total cholesterol can be reduced by 25-34% with a very consistent risk reduction of 24% of death from cardiovascular diseases.

Is rosuvastatin stronger than simvastatin?

Dosage and strength Both Crestor and simvastatin come in a range of strengths. However, the doses between Crestor and simvastatin are not equivalent. Crestor is a lot more potent. For example, 40 mg is a high dose of simvastatin, but you would get that same dose of Crestor in about 10 mg.

Which is the best statin with least side effects?

In the analysis of 135 previous studies, which included nearly 250,000 people combined, researchers found that the drugs simvastatin (Zocor) and pravastatin (Pravachol) had the fewest side effects in this class of medications. They also found that lower doses produced fewer side effects in general.

Can you take pravastatin and simvastatin together?

Lovastatin (Mevacor), simvastatin (Zocor) and pravastatin (Pravachol) should not be used with the fibrate cholesterol drug gemfibrozil, for example, because of the risk of muscle injury.