What can be used instead of cisapride?

The alternatives include acid suppressing drugs, domperidone, metoclopramide and laxatives. Several drugs currently under development, especially the new 5HT4 agonists and GABA-B agonists, may also be of value. Cisapride still has a limited role in gastroparesis.

Is cisapride available in the US?

Cisapride is only available in the United States to special patients who are signed up by their doctors. Talk to your doctor or pharmacist about whether you should be taking cisapride. Cisapride may cause serious irregular heart beats, which can lead to death.

What is the generic name for cisapride?

Propulsid (cisapride) is a “prokinetic” agent that increases muscle contractions of the lower esophagus and the lower esophagus sphincter used to treat gastric reflux (the regurgitation of stomach acid into the esophagus), which is usually experienced as heartburn.

Why was cisapride removed from the market?

Introduction. Janssen Pharmaceutica, in consultation with the FDA, has decided to stop marketing the prokinetic agent cisapride (Propulsid®) on July 14, 2000 due to the risk of serious cardiac arrhythmias and death associated with this agent.

Can cisapride be given with food?

Cisapride is given by mouth in the form of a compounded tablet, capsule, or liquid. It may be given with or without food, but if your pet vomits when dosed on an empty stomach, give future doses with food or a treat. Measure liquid forms of this medication carefully.

What are the symptoms of megacolon?

What are the symptoms of toxic megacolon?

abdominal pain.
bloating of the abdomen (distention)
abdominal tenderness.
fever.
rapid heart rate (tachycardia)
shock.
bloody or profuse diarrhea.
painful bowel movements.

Is cisapride the same as lactulose?

The lactulose improves fecal consistency while cisapride gets the colon to contract and expel contents. You may need to increase the dose of Cisapride over time (chronic care cases).

What is the brand name for domperidone?

Domperidone, sold under the brand name Motilium among others, is a medication used as an antiemetic, gastric prokinetic agent, and galactagogue. It may be taken by mouth or rectally, and is available as a tablet, orally disintegrating tablets, suspension, and suppositories.

Why phenylpropanolamine is banned?

Phenylpropanolamine has been voluntarily removed from the market in the United States by its manufactures because of concerns raised about its ability to precipitate a stroke when used, or perhaps abused, as an appetite suppressant Kernan et al (2000).

Does cisapride make you sleepy?

Before using cisapride, tell your doctor if you regularly use other medicines that make you sleepy (such as cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by cisapride.

Is cisapride a laxative?

The effects of cisapride partly outlasted active medication by at least four weeks. It is concluded that cisapride improves bowel habits in patients with idiopathic constipation and reduces laxative consumption.