What does the SIRT6 gene do?

SIRT6 is a chromatin-associated protein that is required for normal base excision repair and double-strand break repair of DNA damage in mammalian cells. SIRT6 promotes the repair of DNA double-strand breaks by the process of non-homologous end joining and homologous recombination.

Can you not age sirtuin 6?

SIRT6 Activator® is a specially curated, all natural product, derived from seaweed. It is the first and only of its kind in the world. Activating Sirtuin 6 promotes DNA repair, reduces genomic instability, reduces inflammation and is key in the fight against ageing.

What activates SIRT6?

Quercetin thus activates Sirt6-dependent deacetylation of its physiological histone substrates.

How do you increase your sirtuins?

An increase in the cellular NAD+/NADH ratio will increase sirtuin activity. NMN, NR supplementation, CR or physical activity increases cellular NAD+ levels.

Where is SIRT6 found?

SIRT1 and SIRT2 are found in the nucleus as well as the cytosol, SIRT3, SIRT4, and SIRT5 in the mitochondria and SIRT6 and SIRT7 in the nucleus [16,17,18,19].

Where does the protein SIRT6 come from?

Tocris Summary for SIRT6 Gene Silent information regulator (Sir2)-like family deacetylases (also known as sirtuins) are a group of enzymes closely related to histone deacetylases. These enzymes can be found in the cytoplasm, mitochondria or nucleus of the cell and are ubiquitously expressed.

Does resveratrol activate SIRT6?

Resveratrol is a widely studied polyphenolic12 antioxidant and is known to increase the deacetylation activity of SIRT1 through a mechanism that is still not fully understood. Here we showed that anthocyanidins strongly increase SIRT6 deacetylation activity in vitro.

What foods contain SIRT6?

Foods that contain sirtuin activators include: green tea, turmeric, onions, kale, parsley, miso soup, tofu and other soy products, olives and extra-virgin olive oil, blackcurrants, capers, cocoa, dates, walnuts and turmeric.

How do you increase your lifespan of sirtuins?

Strategies to stimulate sirtuins As mentioned above, intermittent fasting or a simple reduction in daily calorie intake has long been linked to an increase in average life expectancy in several species. Several natural molecules have been identified which are able to activate sirtuins.

What is the sirtuin theory of aging?

Think of autophagy as a vacuum cleaner that travels through the cell and cleans up all the gunk over time. Autophagy also triggers a healthy inflammation response that leads to even more longevity. From metabolism to healthy longevity, the sirtuin theory of aging is opening up a new chapter of nutrigenomics.

How do you activate sirtuin genes?

There are several ways to stimulate the production of sirtuins, the longevity proteins. Examples are intermittent fasting or a simple reduction in daily calorie intake, which have long been linked to an increase in average life expectancy in several species.