What ester produces 4-hydroxybenzoic acid?

What ester produces 4-hydroxybenzoic acid?

Chemical production 4-Hydroxybenzoic acid is produced commercially from potassium phenoxide and carbon dioxide in the Kolbe-Schmitt reaction.

What is hydroxybenzoic acid used for?

Parabens (p-hydroxybenzoic acid) are an important class of preservatives extensively used in the cosmetic and pharmaceutical industries for preparing shampoos, commercial moisturizers, shaving gels, personal lubricants, topical/parenteral pharmaceuticals, spray tanning solutions, and toothpaste.

What is the chemical structure of 4-hydroxybenzoic acid?

4-Hydroxybenzoic acid

Is para hydroxybenzoic acid bad for you?

Acute, subchronic, and chronic studies in rodents indicate that parabens are practically non-toxic. Parabens are rapidly absorbed, metabolized, and excreted. In individuals with normal skin, parabens are, for the most part, non-irritating and non-sensitizing.

What is the density of 4 hydroxybenzoic acid?

1.46 g/cm³
4-Hydroxybenzoic acid/Density

Which is more acidic para hydroxybenzoic acid or meta hydroxybenzoic acid?

+I-Effect and +R-Effect intensifies the negative charge on the carboxylate ion thereby making the carboxylate ion less stable and decreases the acidity of the benzoic acid. So, meta-hydroxybenzoic acid is more acidic than para-hydroxybenzoic acid.

What is the melting point of 4 hydroxybenzoic acid?

215 – 217 °C
4-Hydroxybenzoic acid for synthesis….Pricing & Availability.

Does 4 hydroxybenzoic acid have a phenol group?

4-Hydroxybenzoic acid is a neutral compound with a nutty and phenolic taste. 4-Hydroxybenzoic acid exists in all living species, from bacteria to humans….Structure for FDB010508 (4-Hydroxybenzoic acid)

Is methylparaben safe in skincare?

A number of studies show that methylparaben may cause cancerous skin damage. A similar study suggested that skin damage from exposure to sunlight while using a product containing methylparaben might lead to the formation of cancer. This may be due to the oxidative DNA damage that it could cause.

Is methylparaben safe to eat?

FDA has stated that there is no reason for consumers to be concerned about the use of cosmetics containing parabens. The FDA has also classified methyl and propylparaben as “Generally Regarded As Safe” by medical and toxicological experts for use in preserving food.

What is the melting point of 4 methoxybenzoic acid?

363.2°F (184°C)
p-Anisic acid/Melting point

Why does 4 hydroxybenzoic acid have a higher melting point than salicylic acid?

Intermolecular Hydrogen Bonds in 4-hydroxybenzoic acid Therefore both groups can be used for hydrogen bonds between molecules. This results in more extensive hydrogen bonds and higher melting point for 4-hydroxybenzoic acid.

Is 4-hydroxybenzoic acid soluble in water?

It is a white crystalline solid that is slightly soluble in water and chloroform but more soluble in polar organic solvents such as alcohols and acetone. 4-Hydroxybenzoic acid is primarily known as the basis for the preparation of its esters, known as parabens, which are used as preservatives in cosmetics and some ophthalmic solutions.

How do you make 4-hydroxybenzoic acid in the laboratory?

It can also be produced in the laboratory by heating potassium salicylate with potassium carbonate to 240 °C, followed by treating with acid. 4-Hydroxybenzoic acid has about one tenth the acidity of benzoic acid, having an acid dissociation constant Ka = 3.3 × 10−5 M at 19 °C.

What is the LD50 of 4-hydroxybenzoic acid?

The LD 50 is 2200 mg/kg in mice (oral). 4-Hydroxybenzoic acid has estrogenic activity both in vitro and in vivo, and stimulates the growth of human breast cancer cell lines. It is a common metabolite of paraben esters, such as methylparaben.

What does 4-hydroxybenzoate 1-hydroxylase do?

The enzyme 4-hydroxybenzoate 1-hydroxylase transforms 4-hydroxybenzoate, NAD (P)H, 2 H + and O 2 into hydroquinone, NAD (P) +, H 2 O and CO 2. This enzyme participates in 2,4-dichlorobenzoate degradation. It can be found in Candida parapsilosis .