What is a high level of anti-CCP?

What Do the Results of an Anti-CCP Test Mean? An anti-CCP result up to 20 u/mL is considered negative, according to the Hospital for Special Surgery. At 20u/mL and higher, an anti-CCP test is considered positive and, with other symptoms and factors, is usually a sign of rheumatoid arthritis.

Why would CCP be high?

Elevated Blood Levels of CCP Are Associated with Developing Rheumatoid Arthritis. In patients with joint pain, high baseline levels of cyclic citrullinated peptide mandate close follow-up. Rheumatoid arthritis (RA) develops from an identifiable preclinical stage to frank disease.

Can anti-CCP be lowered?

In a study of over 200 people, lower vitamin D levels were linked to higher anti-CCP antibody levels [17]. Vitamin D may help lower anti-CCP antibodies by suppressing overactive immune cells that attack the body’s own proteins and tissues [17].

Is anti-CCP test accurate?

With a specificity of about 96% and a positive likelihood ratio of about 14, anti-CCP assists with the diagnosis of RA. It is present in only a quarter to half of patients before or at diagnosis, so a negative result does not rule out RA. It can also predict aggressive joint erosion.

Is CCP high in lupus?

All SLE patients positive of anti-CCP were submitted to hand and feet X-rays. Anti-CCP was positive in 15 of 109 SLE patients, and one of them had confirmed the diagnosis of rhupus. This prevalence was significantly higher than in healthy controls (p = 0.0004) and lower than in RA patients (p < 0.0001).

What is normal RA factor?

The RA factor normal range is below 14 IU/ml for the Rheumatoid factor. Any values about 14IU/ml or above are considered high.

Is rheumatoid factor 9 normal?

Normal Rheumatoid Factor Levels Always talk with your doctor to learn more about your test results. The normal range of rheumatoid factor levels is usually between < 14 and < 20 IU/mL. A level above these values is considered a positive result and may indicate rheumatoid arthritis or other disorders [9, 10, 11].