What is a side effect of intrathecal methotrexate?

Intrathecal methotrexate can occasionally cause headaches, dizziness, tiredness, blurred vision or loss of balance for a few hours. It may help to lie down afterwards.

How does methotrexate work biologically?

Methotrexate is an antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities. Methotrexate binds to and inhibits the enzyme dihydrofolate reductase, resulting in inhibition of purine nucleotide and thymidylate synthesis and, subsequently, inhibition of DNA and RNA syntheses.

Why is intrathecal chemotherapy used?

Intrathecal (IT) chemotherapy is used to treat cancers that have entered into the CSF. When a cancer has gotten into the CSF, it may be called CNS (central nervous system) involvement.

Is an epidural intrathecal?

Epidural analgesia is the administration of analgesics into the epidural space. Analgesics can be given either as a single injection or as a continuous infusion via an indwelling catheter. Intrathecal analgesia is the administration of analgesic drugs (as listed above) directly into the CSF in the intrathecal space.

Is intrathecal the same as subarachnoid?

Also known as the subarachnoid space, the intrathecal space is the fluid-filled area located between the innermost layer of covering (the pia mater) of the spinal cord and the middle layer of covering (the arachnoid mater).

Is intrathecal chemotherapy painful?

After intrathecal chemotherapy Having this treatment is not usually painful. Some people may find it uncomfortable or have a headache for a few hours afterwards. Tell your doctor or nurse if you have a headache, as they can give you mild painkillers to help.

Is spinal chemo painful?

You’ll be asked to lie on your side or sit with your head and chest resting on a surface to expose your spine. The area will be numbed with an anesthetic to prepare for the injection. You may feel some pressure but shouldn’t feel pain at the injection site.

What is the purity of M-CSF protein?

Purity: > 95 % as determined by SDS-PAGE. There are 11 M-CSF protein produced in house with high quality which are covering various species. Among these M-CSF proteins, there are 7 Human M-CSF protein, 2 Mouse M-CSF protein, 2 Cynomolgus, Rhesus M-CSF protein.

What does CSF total protein mean?

CSF is a clear fluid that is in the space around the spinal cord and brain. CSF total protein is a test to determine the amount of protein in cerebrospinal fluid (CSF). This test may be helpful in diagnosing tumors, infective polyneuritis (inflammation of several groups of nerve cells), vasculitis, blood in the CSF, and trauma.

How many M-CSF proteins are expressed by different host cells?

All these M-CSF protein are expressed by different host cells. 10 M-CSF proteins are expressed by HEK293 Cells , 1 M-CSF proteins are expressed by Yeast . These M-CSF proteins are produced with different tags, such as His Tag, hFc Tag.

What is a cerebrospinal fluid protein test?

Cerebrospinal fluid (CSF) is a clear bodily fluid that cushions and protects your brain and spinal cord. A CSF protein test involves taking a fluid sample from your spinal column using a needle. This procedure is known as a lumbar puncture or spinal tap.

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