What is a Synovasure aspiration?

The Synovasure Differential Diagnosis Arthritis Panel provides physicians multiple results to help discern between arthritis conditions causing knee pain with similar symptoms and aid in identification of potential secondary arthritis conditions with a single synovial fluid knee aspiration.

What is a Synovasure?

The Synovasure Alpha Defensin Lateral Flow Test is a standalone, rapid device for detecting alpha defensin in synovial fluid, an antimicrobial peptide released into the body through activated neutrophils in response to an infection.

When to use Synovasure?

Synovasure has been designed and validated for use in the diagnosis of periprosthetic joint infection (PJI). It has a reported sensitivity of 97.4% (CI 86.1–99.6%) and specificity of 95.8% (CI 90.5–98.6%), higher than the variable results reported for aspiration by most units.

What is Alpha Defensin Test?

The Alpha-Defensin Test for Diagnosing Periprosthetic Joint Infection in the Setting of an Adverse Local Tissue Reaction Secondary to a Failed Metal-on-Metal Bearing or Corrosion at the Head-Neck Junction. J Arthroplasty.

Is synovial fluid?

Synovial fluid is the thick liquid that lubricates your joints and keeps them moving smoothly. It’s on all of your joints, including in your knees, shoulders, hips, hands, and feet. Joint conditions like arthritis, gout, infections, and bleeding disorders can change how your synovial fluid looks and feels.

What is a Synovasure test?

The Synovasure Lateral Flow Test Kit detects proteins called human alpha defensins in the synovial fluid of patients with a total joint replacement in approximately 10 minutes. Alpha defensins are antimicrobial proteins released by activated neutrophils (white blood cells) in response to infection.

What causes alpha defensin protein?

Structure of defensin HNP-3. Alpha defensins are a family of mammalian defensin peptides of the alpha subfamily. In mammals they are also known as cryptdins and are produced within the small bowel. Defensins are produced constitutively and/or in response to microbial products or proinflammatory cytokines.

What is fluid in knee called?

How do defensins help prevent viral infection?

The effect of defensins on viral infection is specific to the defensin, virus and target cell. Furthermore, defensins can inhibit or enhance viral infection. This effect is achieved through direct interaction with viral envelopes or through interactions with potential target cells.