What is BSAP test?

Alkaline Phosphatase, Bone Specific – The Bone-Specific Alkaline Phosphatase (BSAP) assay provides a general index of bone formation and a specific index of total osteoblast activity.

What does a high bone alkaline phosphatase mean?

Instead, it can indicate a bone disorder, such as Paget’s Disease of Bone, a condition that causes your bones to become abnormally large, weak, and prone to fractures. Moderately high levels of alkaline phosphatase may indicate conditions such as Hodgkin lymphoma, heart failure, or a bacterial infection.

What happens if alkaline phosphatase is high?

High levels Higher-than-normal levels of ALP in your blood may indicate a health concern with your liver or gallbladder. This could include a blockage in your bile ducts, gallstones, cirrhosis, liver cancer, and some forms of hepatitis.

What bone disorders cause high ALP?

High ALP levels can be caused by bone diseases, such as Paget’s disease, osteomalacia, rickets, bone tumors, or tumors that have spread from another part of the body to the bone, or by overactive parathyroid glands (hyperparathyroidism). Normal healing of a bone fracture can also raise ALP levels.

What is the function of alkaline phosphatase in bone?

Bone ALP is a major regulator of bone mineralization. It hydrolyzes inorganic pyrophosphate which is a naturally occurring inhibitor of mineralization. Bone ALP also provides inorganic phosphate (from pyrophosphate and organic phosphomonoesters) for the synthesis of hydroxyapatite [7,8].

What is a bone specific alkaline phosphatase test?

Takeaway. The ALP bone isoenzyme test is a blood test that measures the levels of ALP-2 in your bones. The test can detect abnormal levels of bone growth that may indicate a bone disease or another serious condition such as leukemia or hyperparathyroidism.

Should I worry about elevated alkaline phosphatase?

While alkaline phosphatase may not necessarily cause harm to the body itself, elevated levels are associated with cancer, bone, liver, and kidney diseases [7].

What are the symptoms of alkaline phosphatase?

Symptoms of High Alkaline Phosphatase

Itching.
Nausea and vomiting.
Weight loss.
Fatigue.
Weakness.
Jaundice.
Swelling and pain in your stomach.
Dark-colored urine and/or light-colored stool.

Is ALP elevated in nephrotic syndrome?

In conclusion, an elevated ALP level was independently associated with poor renal outcome in patients with type 2 diabetes mellitus and nephrotic-range proteinuria after multivariate adjustment.

Does osteoporosis cause high ALP?

Therefore, ALP can be used as a marker of bone turnover instead of BSAP in elderly women. High levels of ALP in elderly women suggest the presence of osteoporosis. Many women experience osteoporosis after menopause. If liver function is normal, bone metabolism can be considered to be the cause of increase in ALP.

What is a normal bone alkaline phosphatase?

The ALP bone isoenzyme range for healthy adults is 12.1 to 42.7. Children have higher levels of ALP bone isoenzyme. ALP-2 is also elevated in people with broken bones.