What is in hyper-CVAD?

Hyper-CVAD includes the drugs cyclophosphamide, vincristine sulfate, doxorubicin hydrochloride (Adriamycin), and dexamethasone. It also includes the drugs methotrexate and cytarabine.

What is hyper-CVAD protocol?

An abbreviation for a chemotherapy combination used to treat some types of acute lymphoblastic leukemia (ALL) and non-Hodgkin lymphoma (NHL). Hyper-CVAD regimen includes the drugs cyclophosphamide, vincristine sulfate, doxorubicin hydrochloride (Adriamycin), and dexamethasone.

How long is hyper-CVAD?

Each cycle of hyper-CVAD lasts 21 days. But if you have hyper-CVAD before a stem cell transplant, you usually only have 2 cycles of each schedule.

What is mini hyper-CVAD?

The modified hyper-CVAD regimen is a combination of chemotherapy drugs including cyclophosphamide, vincristine, Adriamycin, dexamethasone and pegylated asparaginase given together for one “course” of treatment.

How is hyper CVAD given?

HyperCVAD Part A usually requires a 4 – 5 day stay in a hospital. Typically, cyclophosphamide, doxorubicin, vincristine, and dexamethasone are all given in the hospital on Days 1 – 4 of each cycle. Vincristine may be given in the clinic on Day 11 and dexamethasone is usually taken at home on Days 11 – 14.

How do you give hyper CVAD?

Schedule

Cyclophosphamide intravenous (I.V.) infusion, usually given over three hours, every 12 hours (twice daily) on Days 1,2,3 (six doses total)
Mesna I.V. infusion, usually given over 24 hours on Days 1,2,3, ending on Day 4.
Vincristine I.V. infusion, usually given over 15 minutes on Days 4 and 11.

How is hyper CVAD administered?

Hyper-CVAD is given as hyperfractionated therapy, in which the total daily dose is divided into smaller doses and given more than once a day. This combination may also be used with other drugs or treatments or to treat other types of cancer.

What is hyper Cytoxan?

Detailed Description: The hyper-CVAD regimen is a combination of chemotherapy drugs including cyclophosphamide, vincristine, Adriamycin, and dexamethasone given together to for one “course” of treatment. This alternates with a course or combination of the chemotherapy drugs methotrexate and cytarabine.