What is the best skin substitute?

From the practical point of view, the skin substitutes are best classified as temporary or permanent and synthetic or biological.

Synthetic skin substitutes.
Biobrane®
Dermagraft®
Integra®
Apligaft®
Matriderm®
OrCel®
Hyalomatrix®

Is there a substitute for skin?

Cellular autologous skin substitutes From the name, cultured skin substitutes indicate grafting materials that have both epidermal and dermal components. It is an autologous graft so there is minimal risk of infection transmission.

What is TransCyte made of?

TransCyte ® is a temporary skin substitute made of a synthetic polymeric epidermal membrane and human neonatal fibroblasts cultured on a scaffold of porcine collagen coated with bio-absorbable polyglactin and containing a silicone covered nylon mesh attached to it [12,149, 176] .

What is an acellular dermal replacement?

Acellular dermal replacement (ADR; Integra™ Dermal Regeneration Template, Integra™ LifeSciences, Plainsboro, NJ) is an artificial bilayer skin replacement system that aids in the formation of a new dermis.

What is apligraf?

Apligraf® (Organogenesis, Canton, MA) is a bi-layered bioengineered skin substitute and was the first engineered skin US Food and Drug Administration (FDA)-approved to promote the healing of ulcers that have failed standard wound care.

What is STSG?

A split-thickness skin graft (STSG), by definition, refers to a graft that contains the epidermis and a portion of the dermis, which is in contrast to a full-thickness skin graft (FTSG) which consists of the epidermis and entire dermis.

Is TheraSkin FDA approved?

TheraSkin is marketed by Soluble Systems, and tissue is provided by the Skin and Wound Allograft Institute (SWAI), a wholly-owned subsidiary of LifeNet Health, Inc. SWAI (Virginia Beach, VA, USA) is registered with FDA as an establishment producing HCT/Ps.

What is red breast syndrome?

Red breast syndrome (RBS) represents an inflammatory condition that rarely occurs in the setting of acellular dermal matrix use after prosthetic reconstruction. It is characterized by erythema or rubor that occurs directly over the ADM, and its appearance resembles that of a cellulitis.

What is ADM mesh?

Device Description. Acellular Dermal Matrix (ADM), a type of surgical mesh, is developed from human skin (such as FlexHD, AlloMax, AlloDerm) or animal skin (such as SurgiMend), in which the cells are removed and the support structure is left in place.

What is dermagraft made of?

Dermagraft contains only human dermal fibroblasts and their secreted products and is devoid of other cell types also found in skin (e.g., macrophages, lymphocytes, endothelial cells, or keratinocytes). The fibroblasts are from a qualified cell bank and have been extensively screened for infectious agents.

How much does apligraf cost?

Apligraf is supplied as a circular disk approximately 7.5 cm in diameter and is intended for single-use. The cost of Apligraf is $1,000 to $1,200 per use. In a 2000 study by Attilasoy, a higher percentage of wounds were healed with Apligraf (55 percent) compared to the control (40 percent).