What is the intrathecal space?

Listen to pronunciation. (IN-truh-THEE-kul) Describes the fluid-filled space between the thin layers of tissue that cover the brain and spinal cord.

Can vincristine be given intrathecally?

Vincristine has a high neurotoxicity level. If given intrathecally by accident, it can cause ascending radiculomyeloencephalopathy, which is almost always fatal. The authors report a rare case in which vincristine was accidentally injected intrathecally into a 32-year-old man.

How do you give intrathecal methotrexate?

Intrathecal methotrexate is given through a needle which is inserted in one of the spaces between the bones in the lower back into the CSF, usually under general anaesthesia. This is known as a lumbar puncture. When drugs are given in this way, they are said to be given intrathecally.

Is epidural a shot?

An epidural injection is an injection of medication into the space around the spinal cord, also known as the epidural space, to provide temporary or prolonged relief from pain or inflammation.

Why did they stop making vincristine?

Product will be available for patients in the U.S. as early in 2020 as possible,” Teva said. After Teva decided to give up production of vincristine, Pfizer said it was unable to keep up with supply. The shortage that materialized led doctors to protest.

When do you give intrathecal methotrexate?

Intrathecal chemotherapy may be given if a cancer has spread to the CSF, or if there is a risk it could. Only certain chemotherapy drugs can be given in this way. The chemotherapy drugs that are most commonly given intrathecally (with a lumbar puncture) are: methotrexate.

What is intrathecal drug administration?

• Intrathecal drug administration is the introduction of a therapeutic substance into the cerebrospinal fluid by injection into the subarachnoid space of the spinal cord to bypass the blood-brain barrier. • The main indications are for anesthesia and pain management.

What is an intrathecal route?

The route of administration is sometimes simply referred to as “intrathecal”; however, the term is also an adjective that refers to something occurring in or introduced into the anatomic space or potential space inside a sheath, most commonly the arachnoid membrane of the brain or spinal cord (under which is the subarachnoid space ).

What is the solubility of intrathecal injections?

The volume of intrathecal injections ranges from 0.5ml to 5ml. Drug solubility in such a small volume can be a challenge for lipophilic agents. Conversion of drugs to their water soluble salts (eg, gentamicin sulphate) or use of buffers can enhance solubility.

How are intrathecal injections made?

Aseptic techniques are used for the preparation and assembly of intrathecal injections and the drug solution is filtered using a 0.2Âµm filter. Also, intrathecal formulations must be preservative-free.