What is transplant related mortality?

Transplant-related mortality (TRM) is defined as death due to causes unrelated to the underlying disease: Patients relapsing are censored as surviving at the time of relapse.

What is non relapse mortality definition?

NRM was defined as death without recurrent or progressive disease after allo-HSCT. Probabilities of NRM were estimated with the use of cumulative incidence curves, with relapse viewed as a competing risk.

What is Allo BMT?

An allogeneic stem cell transplant uses healthy blood stem cells from a donor to replace your diseased or damaged bone marrow. An allogeneic stem cell transplant is also called an allogeneic bone marrow transplant. A donor may be a family member, an acquaintance or someone you don’t know.

What is the mortality rate of autologous stem cell transplant?

Results: Forty-two patients (2.8%) died from treatment-related reasons <100 d from ASCT. The median time to death was 38 d from ASCT (0-99). The risk of TRM varied according to the diagnoses. The highest risk was observed in patients with AL amyloidosis (24%) followed by NHL (4.4%) and MM (1.9%).

What is HSCT?

HSCT (haematopoietic stem cell transplantation) is an intense chemotherapy treatment for MS. It aims to stop the damage MS causes by wiping out and then regrowing your immune system, using your stem cells.

What is involved in stem cell transplant?

To prepare for a stem cell transplant, you receive chemotherapy to kill the diseased cells and malfunctioning bone marrow. Then, transplanted blood stem cells are put into your bloodstream. The transplanted stem cells find their way to your marrow, where — ideally — they begin producing new, healthy blood cells.

What is haplo transplant?

A haploidentical transplant (haplo) is a half matched stem cell transplant from a family member. Haplo donors can be parents, children, siblings, and sometimes cousins of the patient. A biologic parent or a biologic child is always a half match to the patient, based on genetics.

Can a stem cell transplant be fatal?

Between 30% and 70% of patients with a donor stem cell transplant get some form of GvHD. It may be mild, serious, or even life threatening.

What is HCT transplant?

Overview. Hematopoietic cell transplantation (HCT) is the intravenous infusion of hematopoietic stem and progenitor cells designed to establish marrow and immune function in patients with a variety of acquired and inherited malignant and nonmalignant disorders.

What is HSCT TMA?

Transplant-associated thrombotic microangiopathy (TA-TMA) is an increasingly recognized complication of hematopoietic stem cell transplant (HSCT) with high morbidity and mortality.